Biotin-PEG5-Amine With Cas.113072-75-6 Is For Chemical Modifications

Introduction

The Biotin-PEG5-Amine With Cas.113072-75-6 is used for modifying proteins or surfaces such as beads, nanoparticles and self-assembled monolayers. Modification of proteins adds polyethylene glycol (PEG)n spacers, which impart increased water solubility, reduced immunogenicity of the labeled molecule and enhanced in vivo stability in solution. Functionalization of solid surfaces, such as quantum dots, self-assembled monolayers and nanoparticles, with polyethylene glycol spacers significantly reduces non** protein binding. (PEG)n amine reagents used with (PEG)n amine reagents in surface modification can form a hy**hilic “lawn” of methyl ether-** PEGs with periodic exposed carboxy-** PEGs. The exposed carboxy groups can be coupled to affinity ligands using the carbodiimide coupling reaction with EDC and sulfo-NHS.

Typical PEGylation reagents contain heterogeneous mixtures of different PEG chain lengths; however, our PEGylation reagents are homogenous compounds of defined molecular weight and spacer length, providing ** in optimizing modification applications.